We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …

Viruses are nanosized, genome-filled protein containers with remarkable thermodynamic
and mechanical properties. They form by spontaneous self-assembly inside the crowded …

Viruses play a role in a significant portion of human diseases, as well as those of other
animals, plants, and bacteria. This chapter focuses on the use of theoretical and …

The advent of nanoscience and nanotechnology and the development of atomic force
microscopy and other single-molecule techniques are leading to a renewed look at viruses …

In this perspective article, we focus on recent developments in the theory of charge effects in
biological DNA-related systems. The electrostatic effects on different levels of DNA …

Highlights•Review of the most recent studies in Mechanical Virology, using AFM nano-
indentation.•Mechanics of structural capsid changes during maturation.•Uncoating …

Herpes simplex virus type 1 (HSV1) capsids undergo extensive structural changes during
maturation and DNA packaging. As a result, they become more stable and competent for …

The propensity for capsid disassembly and uncoating of human adenovirus is modulated by
interactions with host cell molecules like integrins and alpha defensins. Here, we use atomic …

The current rapid growth in the use of nanosized particles is fueled in part by our increased
understanding of their physical properties and ability to manipulate them, which is essential …

Atomic force microscopy has recently provided highly precise measurements of mechanical
properties of various viruses. However, molecular details underlying viral mechanics remain …