Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

[HTML][HTML] Impact of the natural compound urolithin A on health, disease, and aging

D D'Amico, PA Andreux, P Valdés, A Singh… - Trends in molecular …, 2021 - cell.com
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …

Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

M Zhang, S Cui, B Mao, Q Zhang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …

The impact of ellagitannins and their metabolites through gut microbiome on the gut health and brain wellness within the gut–brain axis

R Banc, ME Rusu, L Filip, DS Popa - Foods, 2023 - mdpi.com
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods,
such as pomegranates, berries, and nuts. The consumption of ETs has often been …

Polyphenols and their effects on muscle atrophy and muscle health

T Nikawa, A Ulla, I Sakakibara - Molecules, 2021 - mdpi.com
Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced
protein synthesis/accelerated protein degradation. Various conditions, such as denervation …

Urolithins: a comprehensive update on their metabolism, bioactivity, and associated gut microbiota

R García‐Villalba, JA Giménez‐Bastida… - Molecular nutrition & …, 2022 - Wiley Online Library
Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins
and ellagic acid, are discovered by the research group in humans almost 20 years ago …

Interactions between gut microbiota and polyphenols: new insights into the treatment of fatigue

C Luo, X Wei, J Song, X Xu, H Huang, S Fan, D Zhang… - Molecules, 2022 - mdpi.com
Fatigue seriously affects people's work efficiency and quality of life and has become a
common health problem in modern societies around the world. The pathophysiology of …

Nutraceuticals/drugs promoting mitophagy and mitochondrial biogenesis may combat the mitochondrial dysfunction driving progression of dry age-related macular …

LM Lewis Luján, MF McCarty, JJ Di Nicolantonio… - Nutrients, 2022 - mdpi.com
In patients with age-related macular degeneration (AMD), the crucial retinal pigment
epithelial (RPE) cells are characterized by mitochondria that are structurally and functionally …

[HTML][HTML] Targeting aging with urolithin A in humans: A systematic review

AH Kuerec, XK Lim, ALY Khoo, E Sandalova… - Ageing Research …, 2024 - Elsevier
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review
assesses the potential geroprotective effect of UA in humans. In five studies including 250 …

Effects of urolithin A on mitochondrial parameters in a cellular model of early Alzheimer disease

C Esselun, E Theyssen, GP Eckert - International journal of molecular …, 2021 - mdpi.com
(1) Background: Ellagitannins are natural products occurring in pomegranate and walnuts.
They are hydrolyzed in the gut to release ellagic acid, which is further metabolized by the …