Therapeutically harnessing extracellular vesicles
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …
from the study of fundamental biology to a subject of significant clinical relevance. The …
Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
Microglial activation and tau propagate jointly across Braak stages
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
[HTML][HTML] Microglia in neuroinflammation and neurodegeneration: from understanding to therapy
L Muzio, A Viotti, G Martino - Frontiers in Neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …
The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Synergy between amyloid-β and tau in Alzheimer's disease
Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
HS Kwon, SH Koh - Translational neurodegeneration, 2020 - Springer
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …
ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease
DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …