Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …

Redox state is a term used widely in the research field of free radicals and oxidative stress.
Unfortunately, it is used as a general term referring to relative changes that are not well …

Glutathione (GSH) is the major cellular thiol participating in cellular redox reactions and
thioether formation. This article serves as introduction to the FRBM Forum on glutathione …

Cell survival requires multiple factors, including appropriate proportions of molecular oxygen
and various antioxidants. Although most oxidative insults can be overcome by the cell's …

Diverse functions of eukaryotic cells are optimized by organization of compatible chemistries
into distinct compartments defined by the structures of lipid-containing membranes …

During the past few years, considerable progress has been made in understanding how
plants protect themselves against oxidative stress. Genes encoding plant antioxidant …

Understanding the dynamics of redox elements in biologic systems remains a major
challenge for redox signaling and oxidative stress research. Central redox elements include …

▪ Abstract New methods to measure thiol oxidation show that redox compartmentation
functions as a mechanism for specificity in redox signaling and oxidative stress. Redox …