[PDF][PDF] Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology

F Borghi, A Saiardi - Biochemical Society Transactions, 2023 - portlandpress.com
Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing
attention due to the many functions it appears to perform within mammalian cells. This essay …

Inorganic polyphosphate and the regulation of mitochondrial physiology

RT Da Costa, LM Riggs… - Biochemical Society …, 2023 - portlandpress.com
Inorganic polyphosphate (polyP) is an ancient polymer that is well-conserved throughout
evolution. It is formed by multiple subunits of orthophosphates linked together by …

[HTML][HTML] Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis

B Duvvuri, LM Pachman, P Hermanson, T Wang… - Journal of …, 2023 - Elsevier
Objectives To elucidate mechanisms contributing to skeletal muscle calcinosis in patients
with juvenile dermatomyositis. Methods A well-characterized cohorts of JDM (n= 68) …

COVID‐19 and neurodegeneration: The mitochondrial connection

CA Denaro, YI Haloush, SY Hsiao, JJ Orgera… - Aging …, 2022 - Wiley Online Library
There is still a significant lack of knowledge regarding many aspects of the etiopathology
and consequences of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

[HTML][HTML] Enzymatic depletion of mitochondrial inorganic polyphosphate (polyP) increases the generation of reactive oxygen species (ROS) and the activity of the …

V Hambardikar, M Guitart-Mampel, ER Scoma… - Antioxidants, 2022 - mdpi.com
Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout
evolution and present in all studied organisms. In mammals, it shows a high co-localization …

[HTML][HTML] Human prune regulates the metabolism of mammalian inorganic polyphosphate and bioenergetics

ER Scoma, RT Da Costa, HH Leung, P Urquiza… - International journal of …, 2023 - mdpi.com
Inorganic polyphosphate (polyP) is an evolutionarily conserved and ubiquitous polymer that
is present in all studied organisms. PolyP consists of orthophosphates (Pi) linked together by …

[HTML][HTML] Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder

A Gasparyan, D Navarro, F Navarrete… - Pharmacological …, 2023 - Elsevier
Fetal alcohol spectrum disorder (FASD) includes neuropsychiatric disturbances related to
gestational and lactational ethanol exposure. Available treatments are minimal and do not …

No life on this planet without PHB

D Seebach - Helvetica Chimica Acta, 2023 - Wiley Online Library
The history of discovery by Rosetta Reusch of oligo‐and poly‐β‐hydroxybutyrates (OHBs
and PHBs) consisting of less than ca. 150 HB units is described. These 'short …

[HTML][HTML] Modulation of ATP production influences inorganic polyphosphate levels in non-athletes' platelets at the resting state

T Ushiki, T Mochizuki, K Suzuki, M Kamimura… - International Journal of …, 2022 - mdpi.com
Platelets produce inorganic polyphosphate (polyP) upon activation to stimulate blood
coagulation. Some researchers have linked polyP metabolism to ATP production, although …

[HTML][HTML] The Glacier Ice Worm, Mesenchytraeus solifugus, Elevates Mitochondrial Inorganic Polyphosphate (PolyP) Levels in Response to Stress

T Osorio, ER Scoma, DH Shain, DS Melissaratos… - Biology, 2022 - mdpi.com
Simple Summary Energy maintenance in living organisms is crucial for survival. The ice-
obligate worm, Mesenchytraeus solifugus, displays an unusual bioenergetic pattern, namely …