An association between human papillomavirus (HPV) infection and the development of
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …

E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino
terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Human papillomavirus (HPV) is the most common sexually transmitted infectious agent
worldwide, being also responsible for 5% of all human cancers. The integration and …

Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of
mortality in developing countries. Persistent infection with high-risk human papillomavirus …

Human papillomavirus (HPV) is a ubiquitous DNA virus that infects squamous epithelia.
Though HPV only encodes 8 genes, it is capable of causing cellular transformation and …

The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s
yet the mechanisms of virally-mediated cellular transformation are still being revealed …

Human papilloma virus (HPV) infection is a major risk factor for a distinct subset of head and
neck squamous cell carcinoma (HNSCC). The current review summarizes the epidemiology …

The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a
helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral …

It is clear that a number of host-cell factors facilitate virus replication and, conversely, a
number of other factors possess inherent antiviral activity. Research, particularly over the …