Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Fibroblasts are one of the most abundant cell types in connective tissues. These cells are
responsible for tissue homeostasis under normal physiological conditions. When tissues are …

There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

Effective tissue engineering requires appropriate selection of cells and scaffold, where the
latter serves as a mechanical and biological support for cell growth and functionality. The …

Scarring, tightly associated with fibrosis, is a significant symptomatic clinical problem.
Interleukin 10 (IL-10) has been identified as a candidate scar-improving therapy based on …

Living soft tissues appear to promote the development and maintenance of a preferred
mechanical state within a defined tolerance around a so-called set point. This phenomenon …

Mesenchymal stem cells (MSCs) derived from umbilical cord s (UC‐MSCs) have been
shown to enhance cutaneous wound healing by means of the paracrine activity. Fibroblasts …

The glomerular podocyte is a highly specialized cell, with the ability to ultrafilter blood and
support glomerular capillary pressures. However, little is known about either the genetic …

The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway
represents a promising therapeutic target to prevent fibrosis. We have tested the effects of …

The extracellular matrix (ECM) plays a critical role in regulating cell behavior during tissue
homeostasis and in disease progression. Through a combination of adhesion, contraction …