Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory
responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse …

Neutrophil granulocytes form the first line of host defense against invading pathogens and
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

Inflammatory response leading to organ dysfunction and failure continues to be the major
problem after injury in many clinical conditions such as sepsis, severe burns, acute …

Acute Renal Failure and Sepsis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Biomaterials are regularly used in various types of artificial tissues and organs, such as
oxygenators, plasmapheresis equipment, hemodialysers, catheters, prostheses, stents …

Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …