Transcription activator WCC recruits deacetylase HDA3 to control transcription dynamics and bursting in Neurospora
M Oehler, L Geisser, ACR Diernfellner, M Brunner - Science Advances, 2023 - science.org
RNA polymerase II initiates transcription either randomly or in bursts. We examined the light-
dependent transcriptional activator White Collar Complex (WCC) of Neurospora to …
dependent transcriptional activator White Collar Complex (WCC) of Neurospora to …
Living in a noisy world—origins of gene expression noise and its impact on cellular decision‐making
The expression level of a gene can vary between genetically identical cells under the same
environmental condition—a phenomenon referred to as gene expression noise. Several …
environmental condition—a phenomenon referred to as gene expression noise. Several …
Cis-regulatory control of transcriptional timing and noise in response to estrogen
M Ginley-Hidinger, H Abewe, K Osborne, A Richey… - Cell Genomics, 2024 - cell.com
Cis-regulatory elements control transcription levels, temporal dynamics, and cell-cell
variation or transcriptional noise. However, the combination of regulatory features that …
variation or transcriptional noise. However, the combination of regulatory features that …
[HTML][HTML] Evaluating single-cell variability in proteasomal decay.
Gene expression is a stochastic process that leads to variability in mRNA and protein
abundances even within an isogenic population of cells grown in the same environment …
abundances even within an isogenic population of cells grown in the same environment …
NetREm Network Regression Embeddings reveal cell-type transcription factor coordination for gene regulation
Transcription factor (TF) coordination plays a key role in target gene (TG) regulation via
protein-protein interactions (PPIs) and DNA co-binding to regulatory elements. Single-cell …
protein-protein interactions (PPIs) and DNA co-binding to regulatory elements. Single-cell …
Capturing statistical fluctuations in gene expression activity using discrete stochastic systems
We present a discrete-event system formalism to capture experimentally observed activity of
genes in single cells, where a gene can stochastically switch between an active state …
genes in single cells, where a gene can stochastically switch between an active state …
[HTML][HTML] Reverse tracking from drug-induced transcriptomes through multilayer molecular networks reveals hidden drug targets
Identifying molecular targets of a drug is an essential process for drug discovery and
development. The recent in-silico approaches are usually based on the structure information …
development. The recent in-silico approaches are usually based on the structure information …
Molecular Sequestration Enhances Precision in Timing of Intracellular Events
Expressed gene products often interact ubiquitously with binding sites at nucleic acids and
macromolecular complexes, known as decoys. Binding of transcription factors (TFs) to …
macromolecular complexes, known as decoys. Binding of transcription factors (TFs) to …
Multimodal screen reveals noise regulatory proteins
O Garcia-Blay, X Hu, CL Wassermann, T van Bokhoven… - bioRxiv, 2024 - biorxiv.org
Gene-expression noise can influence cell-fate choices across pathology and physiology.
However, a crucial question persists: do regulatory proteins or pathways exist that control …
However, a crucial question persists: do regulatory proteins or pathways exist that control …
Ribosome demand links transcriptional bursts to protein expression noise
Stochastic variation in protein expression generates phenotypic heterogeneity in a cell
population, and has important role in antibiotic persistence, mutation penetrance, cancer …
population, and has important role in antibiotic persistence, mutation penetrance, cancer …