RNA polymerase II initiates transcription either randomly or in bursts. We examined the light-
dependent transcriptional activator White Collar Complex (WCC) of Neurospora to …

The expression level of a gene can vary between genetically identical cells under the same
environmental condition—a phenomenon referred to as gene expression noise. Several …

Cis-regulatory elements control transcription levels, temporal dynamics, and cell-cell
variation or transcriptional noise. However, the combination of regulatory features that …

Gene expression is a stochastic process that leads to variability in mRNA and protein
abundances even within an isogenic population of cells grown in the same environment …

Transcription factor (TF) coordination plays a key role in target gene (TG) regulation via
protein-protein interactions (PPIs) and DNA co-binding to regulatory elements. Single-cell …

We present a discrete-event system formalism to capture experimentally observed activity of
genes in single cells, where a gene can stochastically switch between an active state …

Identifying molecular targets of a drug is an essential process for drug discovery and
development. The recent in-silico approaches are usually based on the structure information …

Expressed gene products often interact ubiquitously with binding sites at nucleic acids and
macromolecular complexes, known as decoys. Binding of transcription factors (TFs) to …

Gene-expression noise can influence cell-fate choices across pathology and physiology.
However, a crucial question persists: do regulatory proteins or pathways exist that control …

Stochastic variation in protein expression generates phenotypic heterogeneity in a cell
population, and has important role in antibiotic persistence, mutation penetrance, cancer …