Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
R Hammoud, DJ Drucker - Nature Reviews Endocrinology, 2023 - nature.com
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1)
exhibit incretin activity, meaning that they potentiate glucose-dependent insulin secretion …
exhibit incretin activity, meaning that they potentiate glucose-dependent insulin secretion …
Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease
JM Yabut, DJ Drucker - Endocrine Reviews, 2023 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …
The expanding incretin universe: from basic biology to clinical translation
DJ Drucker, JJ Holst - Diabetologia, 2023 - Springer
Incretin hormones, principally glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1), potentiate meal-stimulated insulin secretion through direct …
glucagon-like peptide-1 (GLP-1), potentiate meal-stimulated insulin secretion through direct …
GIPR is predominantly localized to nonadipocyte cell types within white adipose tissue
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) augments
glucose-dependent insulin secretion through its receptor expressed on islet β-cells. GIP also …
glucose-dependent insulin secretion through its receptor expressed on islet β-cells. GIP also …
Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling
The glucagon-like peptide-1 receptor (GLP1R) is a class BG protein-coupled receptor
(GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are …
(GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are …
DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
CE Stieger, Y Park, MAR de Geus… - Angewandte Chemie …, 2022 - Wiley Online Library
We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐
phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective …
phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective …
DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets
C Cai, C Meng, S He, C Gu, T Lhamo, D Draga, D Luo… - Cell & Bioscience, 2022 - Springer
Background Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes,
is a major cause of vision loss among middle-aged people worldwide, and the number of …
is a major cause of vision loss among middle-aged people worldwide, and the number of …
Omarigliptin inhibits brain cell ferroptosis after intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is a disastrous disease without effective treatment. An
extensive body of evidence indicate that neuronal ferroptosis is a key contributor to …
extensive body of evidence indicate that neuronal ferroptosis is a key contributor to …
[HTML][HTML] Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release
MP Greenwood, M Greenwood, S Bárez-López… - Molecular …, 2023 - Elsevier
Objectives The excessive release of the antidiuretic hormone vasopressin is implicated in
many diseases including cardiovascular disease, diabetes, obesity, and metabolic …
many diseases including cardiovascular disease, diabetes, obesity, and metabolic …
[HTML][HTML] GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells
Abstract Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic
polypeptide receptor (GIPR) are transmembrane receptors involved in insulin, glucagon and …
polypeptide receptor (GIPR) are transmembrane receptors involved in insulin, glucagon and …