Molecular mechanism of nucleotide excision repair
WL de Laat, NGJ Jaspers… - Genes & …, 1999 - genesdev.cshlp.org
From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …
genetic information is stored is not chemically inert. DNA integrity is challenged by the …
Mechanisms of interstrand DNA crosslink repair and human disorders
S Hashimoto, H Anai, K Hanada - Genes and Environment, 2016 - Springer
Interstrand DNA crosslinks (ICLs) are the link between Watson-Crick strands of DNAs with
the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both …
the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both …
[图书][B] DNA repair and mutagenesis
An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …
Introduces important new material reflective of the major changes and developments that …
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric
disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 …
disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 …
[HTML][HTML] Mechanism of open complex and dual incision formation by human nucleotide excision repair factors
During nucleotide excision repair in human cells, a damaged DNA strand is cleaved by two
endonucleases, XPG on the 3′ side of the lesion and ERCC1‐XPF on the 5′ side. These …
endonucleases, XPG on the 3′ side of the lesion and ERCC1‐XPF on the 5′ side. These …
Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect
H Fassihi, M Sethi, H Fawcett, J Wing… - Proceedings of the …, 2016 - National Acad Sciences
Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by increased
susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface …
susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface …
Base excision repair of oxidative DNA damage activated by XPG protein
A Klungland, M Höss, D Gunz, A Constantinou… - Molecular cell, 1999 - cell.com
Oxidized pyrimidines in DNA are removed by a distinct base excision repair pathway
initiated by the DNA glycosylase—AP lyase hNth1 in human cells. We have reconstituted …
initiated by the DNA glycosylase—AP lyase hNth1 in human cells. We have reconstituted …
XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients
S Ito, I Kuraoka, P Chymkowitch, E Compe… - Molecular cell, 2007 - cell.com
Mutations in the human XPG gene give rise to an inherited photosensitive disorder,
xeroderma pigmentosum (XP) associated with Cockayne syndrome (XP-G/CS). The clinical …
xeroderma pigmentosum (XP) associated with Cockayne syndrome (XP-G/CS). The clinical …
Nucleotide excision repair and cancer
D Leibeling, P Laspe, S Emmert - Journal of molecular histology, 2006 - Springer
Nucleotide excision repair (NER) is the most versatile and best studied DNA repair system in
humans. NER can repair a variety of bulky DNA damages including UV-light induced DNA …
humans. NER can repair a variety of bulky DNA damages including UV-light induced DNA …
Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G
PK Cooper, T Nouspikel, SG Clarkson, SA Leadon - Science, 1997 - science.org
In normal human cells, damage due to ultraviolet light is preferentially removed from active
genes by nucleotide excision repair (NER) in a transcription-coupled repair (TCR) process …
genes by nucleotide excision repair (NER) in a transcription-coupled repair (TCR) process …