The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

Molecular mechanisms of melatonin-induced alleviation of synaptic dysfunction and
neuroinflammation in Parkinson’s disease: a Page 1 5070 Abstract. – This review focuses on …

Parkinson's disease (PD) is a common neurological illness that causes several motor and
non-motor symptoms, most characteristically limb tremors and bradykinesia. PD is a slowly …

Aging is the main risk factor for the appearance of age‐related neurodegenerative diseases,
including Alzheimer's disease (AD). AD is the most common form of dementia, characterized …

The aggregation and prion-like propagation of tau are the hallmarks of Alzheimer's disease
(AD) and other tauopathies. However, the molecular mechanisms underlying the assembly …

Vestigial dopaminergic cells in PD have selectivity for a sub-class of hypersensitive neurons
with the nigrostriatal dopamine (DA) tract. DA is modulated in pre-synaptic nerve terminals to …

This study aimed to explore the role of SYNJ1 in Parkinson's disease (PD) and its potential
as a neuroprotective factor. We found that SYNJ1 was decreased in the SN and striatum of …

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in
the nigrostriatal pathway and dopamine deficiency in the striatum. The precise reasons …

Dopaminergic neurons in the substantia nigra pars compacta (SNpc) demonstrate regionally
selective susceptibility in Parkinson's disease (PD) compared to those in the ventral …

Background Previous preliminary work found that Latroeggtoxin-VI (LETX-VI), a
proteinaceous neurotoxin from the eggs of spider Latrodectus tredecimguttatus, could …