Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances

JR Chong, NJ Ashton, TK Karikari, T Tanaka… - Journal of Neurology …, 2021 - jnnp.bmj.com
Discovery and development of clinically useful biomarkers for Alzheimer's disease (AD) and
related dementias have been the focus of recent research efforts. While cerebrospinal fluid …

Relevance of biomarkers across different neurodegenerative diseases

AJ Ehrenberg, A Khatun, E Coomans, MJ Betts… - Alzheimer's research & …, 2020 - Springer
Background The panel of fluid-and imaging-based biomarkers available for
neurodegenerative disease research is growing and has the potential to close important …

Characterization of pre‐analytical sample handling effects on a panel of Alzheimer's disease–related blood‐based biomarkers: results from the Standardization of …

IMW Verberk, EO Misdorp, J Koelewijn… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Pre‐analytical sample handling might affect the results of Alzheimer's disease
blood‐based biomarkers. We empirically tested variations of common blood collection and …

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease

MJ Wang, SH Yi, J Han, SY Park, JW Jang… - Alzheimer's research & …, 2017 - Springer
Background Soluble amyloid-β (Aβ) oligomers are the major toxic substances associated
with the pathology of Alzheimer's disease (AD). The ability to measure Aβ oligomer levels in …

Machine learning-assisted sensor array based on poly (amidoamine)(PAMAM) dendrimers for diagnosing Alzheimer's disease

L Xu, H Wang, Y Xu, W Cui, W Ni, M Chen… - ACS …, 2022 - ACS Publications
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and the early
diagnosis of AD remains challenging. Here we have developed a fluorescent sensor array …

Diagnostic accuracy of blood-based biomarker panels: a systematic review

A Hardy-Sosa, K León-Arcia… - Frontiers in aging …, 2022 - frontiersin.org
Background Because of high prevalence of Alzheimer's disease (AD) in low-and middle-
income countries (LMICs), there is an urgent need for inexpensive and minimally invasive …

[HTML][HTML] Promising blood biomarkers for clinical use in Alzheimer's disease: a focused update

SA Park, YJ Jang, MK Kim, SM Lee… - Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most-common cause of neurodegenerative dementia, and it
is characterized by abnormal amyloid and tau accumulation, which indicates …

Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer's disease

X Meng, T Li, X Wang, X Lv, Z Sun, J Zhang… - Alzheimer's research & …, 2019 - Springer
Objective The objectives of this study were to investigate whether the plasma levels of
oligomeric amyloid-β (OAβ) were affected in Alzheimer's disease (AD) and to examine the …

Amyloid-beta peptide detection via aptamer-functionalized nanowire sensors exploiting single-trap phenomena

Y Kutovyi, H Hlukhova, N Boichuk, M Menger… - Biosensors and …, 2020 - Elsevier
New highly sensitive direct methods for the early detection of peptides involved in
Alzheimer's disease (AD) are required in order to prolong effective and healthy memory and …

[HTML][HTML] Is liquid biopsy mature enough for the diagnosis of Alzheimer's disease?

X Gong, H Zhang, X Liu, Y Liu, J Liu… - Frontiers in Aging …, 2022 - frontiersin.org
The preclinical diagnosis and clinical practice for Alzheimer's disease (AD) based on liquid
biopsy have made great progress in recent years. As liquid biopsy is a fast, low-cost, and …