Current standards of care in glioblastoma therapy

C Fernandes, A Costa, L Osório, RC Lago… - Exon …, 2017 - exonpublications.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …

Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors

A Lauko, A Lo, MS Ahluwalia, JD Lathia - Seminars in cancer biology, 2022 - Elsevier
Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

[HTML][HTML] Toxicity of concurrent stereotactic radiotherapy and targeted therapy or immunotherapy: a systematic review

SGC Kroeze, C Fritz, M Hoyer, SS Lo, U Ricardi… - Cancer treatment …, 2017 - Elsevier
Background and purpose Both stereotactic radiotherapy (SRT) and immune-or targeted
therapy play an increasingly important role in personalized treatment of metastatic disease …

Current status and recent advances in reirradiation of glioblastoma

G Minniti, M Niyazi, F Alongi, P Navarria, C Belka - Radiation Oncology, 2021 - Springer
Despite aggressive management consisting of maximal safe surgical resection followed by
external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant …

Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme

J Bou-Gharios, G Noël, H Burckel - Cell Death & Disease, 2024 - nature.com
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard
clinical treatment of GBM includes a maximal surgical resection followed by concomitant …

The radiosurgery fractionation quandary: single fraction or hypofractionation?

JP Kirkpatrick, SG Soltys, SS Lo, K Beal… - Neuro …, 2017 - academic.oup.com
Stereotactic radiosurgery (SRS), typically administered in a single session, is widely
employed to safely, efficiently, and effectively treat small intracranial lesions. However, for …

Radiation therapy of glioblastoma

IJ Barani, DA Larson - Current understanding and treatment of gliomas, 2015 - Springer
Glioblastoma multiforme (GBM) is the most common malignant brain tumor that affects
approximately 17,000 patients annually. Clear survival advantages have been …

Antiangiogenic therapy for glioblastoma: current status and future prospects

TT Batchelor, DA Reardon, JF De Groot, W Wick… - Clinical Cancer …, 2014 - AACR
Glioblastoma is characterized by high expression levels of proangiogenic cytokines and
microvascular proliferation, highlighting the potential value of treatments targeting …

[HTML][HTML] New directions in anti-angiogenic therapy for glioblastoma

N Wang, RK Jain, TT Batchelor - Neurotherapeutics, 2017 - Elsevier
Anti-angiogenic therapy has become an important component in the treatment of many solid
tumors given the importance of adequate blood supply for tumor growth and metastasis …

The biology of radiosurgery and its clinical applications for brain tumors

D Kondziolka, SM Shin, A Brunswick, I Kim… - Neuro …, 2015 - academic.oup.com
Stereotactic radiosurgery (SRS) was developed decades ago but only began to impact brain
tumor care when it was coupled with high-resolution brain imaging techniques such as …