Signaling by the small G-protein Rap is under tight regulation by its GEFs and GAPs. These
are multi-domain proteins that are themselves controlled by distinct upstream pathways, and …

Few kinases have been studied as extensively as protein kinase C (PKC), particularly in the
context of cancer. As major cellular targets for the phorbol ester tumor promoters and …

Ras guanyl nucleotide releasing proteins (RasGRPs) are guanyl nucleotide exchange
factors that activate Ras and related GTPases such as Rap. Like Sos proteins, RasGRPs …

Platelets are critical for hemostasis, ie, the body's ability to prevent blood loss at sites of
vascular injury. They patrol the vasculature in a quiescent, non-adhesive state for …

The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated
downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors …

Ca2+ is a universal intracellular signal. The modulation of cytoplasmic Ca2+ concentration
regulates a plethora of cellular processes, such as: synaptic plasticity, neuronal survival …

Apoptosis of endothelial cells is a very important event in various diseases and
angiogenesis. We recently reported that ras guanyl nucleotide releasing protein 2 …

Four Ras guanine nucleotide-releasing proteins (RasGRP1 through 4) belong to the family
of guanine nucleotide exchange factors (GEFs). RasGRPs catalyze the release of GDP from …

Lectins are present throughout the plant kingdom and are reported to be involved in diverse
biological processes. In this study, we provide a comparative analysis of the lectin families …

The molecular mechanisms by which receptors regulate the Ras Binding Domains of the
PIP3‐generating, class I PI3Ks remain poorly understood, despite their importance in a …