Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells

L Keller, K Pantel - Nature Reviews Cancer, 2019 - nature.com
Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …

Progression and metastasis of lung cancer

HH Popper - Cancer and Metastasis Reviews, 2016 - Springer
Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the
process in several isolated steps such as angiogenesis, hypoxia, circulation, and …

Biology, detection, and clinical implications of circulating tumor cells

SA Joosse, TM Gorges, K Pantel - EMBO molecular medicine, 2015 - embopress.org
Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor
cells through the blood circulation is an important intermediate step that also exemplifies the …

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

SA Selamat, BS Chung, L Girard, W Zhang… - Genome …, 2012 - genome.cshlp.org
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

The RNA-binding protein QKI suppresses cancer-associated aberrant splicing

FY Zong, X Fu, WJ Wei, YG Luo, M Heiner, LJ Cao… - PLoS …, 2014 - journals.plos.org
Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has
been implicated in lung tumorigenesis. However, the functional links between splicing …

Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

N Ishaque, ML Abba, C Hauser, N Patil… - Nature …, 2018 - nature.com
Incomplete understanding of the metastatic process hinders personalized therapy. Here we
report the most comprehensive whole-genome study of colorectal metastases vs. matched …

Deep transfer learning enables lesion tracing of circulating tumor cells

X Guo, F Lin, C Yi, J Song, D Sun, L Lin… - Nature …, 2022 - nature.com
Liquid biopsy offers great promise for noninvasive cancer diagnostics, while the lack of
adequate target characterization and analysis hinders its wide application. Single-cell RNA …

Functional studies on viable circulating tumor cells

K Pantel, C Alix-Panabieres - Clinical chemistry, 2016 - academic.oup.com
BACKGROUND Research on circulating tumor cells (CTCs) as new biomarkers has
received great attention over the past decade. In particular, the capture and analysis of …

Evolving concepts in cancer therapy through targeting sphingolipid metabolism

JP Truman, M García-Barros, LM Obeid… - Biochimica et Biophysica …, 2014 - Elsevier
Traditional methods of cancer treatment are limited in their efficacy due to both inherent and
acquired factors. Many different studies have shown that the generation of ceramide in …

Characterization of different CTC subpopulations in non-small cell lung cancer

A Hanssen, J Wagner, TM Gorges, A Taenzer… - Scientific reports, 2016 - nature.com
Circulating tumour cells (CTCs) serve as valuable biomarkers. However, EpCAM positive
CTCs are less frequently detected in NSCLC patients compared to other epithelial tumours …