Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
Progression and metastasis of lung cancer
HH Popper - Cancer and Metastasis Reviews, 2016 - Springer
Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the
process in several isolated steps such as angiogenesis, hypoxia, circulation, and …
process in several isolated steps such as angiogenesis, hypoxia, circulation, and …
Biology, detection, and clinical implications of circulating tumor cells
Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor
cells through the blood circulation is an important intermediate step that also exemplifies the …
cells through the blood circulation is an important intermediate step that also exemplifies the …
Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression
SA Selamat, BS Chung, L Girard, W Zhang… - Genome …, 2012 - genome.cshlp.org
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …
most common histological subtype. Clinical and molecular evidence indicates that lung …
The RNA-binding protein QKI suppresses cancer-associated aberrant splicing
FY Zong, X Fu, WJ Wei, YG Luo, M Heiner, LJ Cao… - PLoS …, 2014 - journals.plos.org
Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has
been implicated in lung tumorigenesis. However, the functional links between splicing …
been implicated in lung tumorigenesis. However, the functional links between splicing …
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
Incomplete understanding of the metastatic process hinders personalized therapy. Here we
report the most comprehensive whole-genome study of colorectal metastases vs. matched …
report the most comprehensive whole-genome study of colorectal metastases vs. matched …
Deep transfer learning enables lesion tracing of circulating tumor cells
X Guo, F Lin, C Yi, J Song, D Sun, L Lin… - Nature …, 2022 - nature.com
Liquid biopsy offers great promise for noninvasive cancer diagnostics, while the lack of
adequate target characterization and analysis hinders its wide application. Single-cell RNA …
adequate target characterization and analysis hinders its wide application. Single-cell RNA …
Functional studies on viable circulating tumor cells
K Pantel, C Alix-Panabieres - Clinical chemistry, 2016 - academic.oup.com
BACKGROUND Research on circulating tumor cells (CTCs) as new biomarkers has
received great attention over the past decade. In particular, the capture and analysis of …
received great attention over the past decade. In particular, the capture and analysis of …
Evolving concepts in cancer therapy through targeting sphingolipid metabolism
JP Truman, M García-Barros, LM Obeid… - Biochimica et Biophysica …, 2014 - Elsevier
Traditional methods of cancer treatment are limited in their efficacy due to both inherent and
acquired factors. Many different studies have shown that the generation of ceramide in …
acquired factors. Many different studies have shown that the generation of ceramide in …
Characterization of different CTC subpopulations in non-small cell lung cancer
A Hanssen, J Wagner, TM Gorges, A Taenzer… - Scientific reports, 2016 - nature.com
Circulating tumour cells (CTCs) serve as valuable biomarkers. However, EpCAM positive
CTCs are less frequently detected in NSCLC patients compared to other epithelial tumours …
CTCs are less frequently detected in NSCLC patients compared to other epithelial tumours …