TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …

Cancer cells that express oncogenic alleles of RAS typically require sustained expression of
the mutant allele for survival, but the molecular basis of this oncogene dependency remains …

Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans
and its incidence continues to rise. Although CSCC usually display a benign clinical …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Although IL-17 is emerging as an important cytokine in cancer promotion and progression,
the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 …

Summary K-Ras and H-Ras share identical effectors and have similar properties; however,
the high degree of tumor-type specificity associated with K-Ras and H-Ras mutations …

M2‑like tumour‑associated macrophages (TAMs) have been demonstrated to promote the
growth of anaplastic thyroid carcinoma (ATC). However, the underlying mechanism of M2 …

Background Inflammation‐based indexes have been used to predict survival and recurrence
in cancer patients. Systemic immune‐inflammation index (SII) was reported to be associated …