Recent developments in computational chemistry and biology have come together in the
“inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze …

Flavonoids are a group of plant constituents called phenolic compounds and correspond to
the nonenergy part of the human diet. Flavonoids are found in vegetables, seeds, fruits, and …

Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

The soil actinomycetes have been important sources of antibiotics, but were nearly
abandoned in recent years in favor of high-throughput target-based screening of chemical …

Natural products and their derivatives play an important role in modern healthcare as
frontline treatments for many diseases and as inspiration for chemically synthesized …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Glycosylation is a chemical transformation that is centrally important in all glycoscience and
related technologies. Catalysts offering good control over reactivity and selectivity in …

The multigene family of enzymes known as glycosyltransferases or popularly known as GTs
catalyze the addition of carbohydrate moiety to a variety of synthetic as well as natural …

Directed evolution can generate a remarkable range of new enzyme properties. Alternate
substrate specificities and reaction selectivities are readily accessible in enzymes from …

A highly efficient di-C-glycosyltransferase GgCGT was discovered from the medicinal plant
Glycyrrhiza glabra. GgCGT catalyzes a two-step di-C-glycosylation of flopropione-containing …