Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
The striatum is thought to play a central role in learning how to choose acts that lead to
reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the …
reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the …
Spatiotemporal pattern of calcium activity in astrocytic network
A Semyanov - Cell calcium, 2019 - Elsevier
Ca 2+ influx through an astrocyte plasma membrane is mediated by ionotropic receptors
and Ca 2+ channels according the electrochemical gradient. These conductances allow …
and Ca 2+ channels according the electrochemical gradient. These conductances allow …
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …
Biochemistry of calcium oscillations
Cytosolic calcium (Ca2+) oscillations are vastly flexible cell signals that convey information
regulating numerous cellular processes. The frequency and amplitude of the oscillating …
regulating numerous cellular processes. The frequency and amplitude of the oscillating …
Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum
CI Lopez-Sanjurjo, SC Tovey, DL Prole… - Journal of cell …, 2013 - journals.biologists.com
Most intracellular Ca2+ signals result from opening of Ca2+ channels in the plasma
membrane or endoplasmic reticulum (ER), and they are reversed by active transport across …
membrane or endoplasmic reticulum (ER), and they are reversed by active transport across …
Disentangling astroglial physiology with a realistic cell model in silico
Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and
generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying …
generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying …
[HTML][HTML] The endoplasmic reticulum and junctional membrane communication during calcium signaling
AKM Lam, A Galione - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
The endoplasmic reticulum is a major organelle in all eukaryotic cells which performs
multiple functions including protein and lipid synthesis and sorting, drug metabolism, and Ca …
multiple functions including protein and lipid synthesis and sorting, drug metabolism, and Ca …
Ratiometric measurement of MAM Ca2+ dynamics using a modified CalfluxVTN
E Cho, Y Woo, Y Suh, BK Suh, SJ Kim… - Nature …, 2023 - nature.com
Mitochondria-associated ER membrane (MAM) is a structure where these calcium-
regulating organelles form close physical contact sites for efficient Ca2+ crosstalk. Despite …
regulating organelles form close physical contact sites for efficient Ca2+ crosstalk. Despite …
The role of dopamine in modulating the structure and function of striatal circuits
Dopamine (DA) is a key regulator of action selection and associative learning. The striatum
has long been thought to be a major locus of DA action in this process. Although all striatal …
has long been thought to be a major locus of DA action in this process. Although all striatal …