Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges
L Ferrazzano, M Catani, A Cavazzini, G Martelli… - Green …, 2022 - pubs.rsc.org
Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis
I Kekessie, K Wegner, I Martinez… - The Journal of …, 2024 - ACS Publications
Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many
attractive targets are poorly tractable by small molecules, generating a need for new …
attractive targets are poorly tractable by small molecules, generating a need for new …
Isolation and functional characterization of hemp seed protein-derived short-and medium-chain peptide mixtures with multifunctional properties for metabolic …
A Cerrato, C Lammi, AL Capriotti, C Bollati… - Food Research …, 2023 - Elsevier
This study aims to obtain a valuable mixture of short-chain peptides from hempseed as a
new ingredient for developing nutraceutical and functional foods useful for preventing …
new ingredient for developing nutraceutical and functional foods useful for preventing …
[HTML][HTML] Model-based optimization strategy for intensification in the chromatographic purification of oligonucleotides
ST Menza, R Prestia, I Fioretti, M Sponchioni - Journal of Chromatography A, 2024 - Elsevier
Oligonucleotides (ONs) are acquiring clinical relevance and their demand is expected to
grow. However, the ON production capacity is currently limited by high manufacturing costs …
grow. However, the ON production capacity is currently limited by high manufacturing costs …
[HTML][HTML] Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects
X Ye, J Li, Z Liu, X Sun, D Wei, L Song, C Wu - Biomedicine & …, 2023 - Elsevier
Fibrosis, a disease characterized by an excess accumulation of extracellular matrix
components, could lead to organ failure and death, and is to blame for up to 45% of all …
components, could lead to organ failure and death, and is to blame for up to 45% of all …
[HTML][HTML] Gas chromatographic techniques and spectroscopic approaches for a deep characterization of Piper gaudichaudianum Kunth essential oil from Brazil
L Cucinotta, A Rotondo, C Coppolino, E Irrera… - … of Chromatography A, 2024 - Elsevier
Piper gaudichaudianum Kunth essential oil (EO) is a natural source of bioactive
components, having multiple therapeutic applications. Its chemical composition is highly …
components, having multiple therapeutic applications. Its chemical composition is highly …
Speeding up sustainable solution-phase peptide synthesis using T3P® as a green coupling reagent: Methods and challenges
A Mattellone, D Corbisiero, L Ferrazzano… - Green …, 2023 - pubs.rsc.org
In peptide synthesis, the issues related to poor sustainability, long reaction times and high
process mass intensity (PMI) are necessary to promote actions aimed at redefining …
process mass intensity (PMI) are necessary to promote actions aimed at redefining …
UV‐based dynamic control improves the robustness of multicolumn countercurrent solvent gradient purification of oligonucleotides
I Fioretti, T Müller‐Späth, L Aumann… - Biotechnology …, 2024 - Wiley Online Library
Therapeutic oligonucleotides (ONs) have great potential to treat many diseases due to their
ability to regulate gene expression. However, the inefficiency of standard purification …
ability to regulate gene expression. However, the inefficiency of standard purification …
Porous platform inks for fast and high‐resolution 3D printing of stationary phases for downstream processing
M Conti, JA Symington, JR Pullen… - Advanced Materials …, 2023 - Wiley Online Library
Purifications of biologics can be improved using 3D printed stationary phases with perfectly
ordered morphology. However, limited spatial resolution and lack of porous materials have …
ordered morphology. However, limited spatial resolution and lack of porous materials have …