Drug discovery is a time-consuming, high-investment, and high-risk process in traditional
drug development. Drug repositioning has become a popular strategy in recent years …

Most rare diseases still lack approved treatments despite major advances in research
providing the tools to understand their molecular basis, as well as legislation providing …

Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

The coronavirus disease (COVID-19) pandemic has affected an estimated 16 million
persons and caused 0.6 million deaths worldwide by September 2020. The pandemic has …

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
and the associated disease COVID-19, requires therapeutic interventions that can be rapidly …

Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

Bioactive small molecules, such as drugs or metabolites, bind to proteins or other macro-
molecular targets to modulate their activity, which in turn results in the observed phenotypic …

In drug discovery, network‐based approaches are expected to spotlight our understanding
of drug action across multiple layers of information. On one hand, network pharmacology …

The recent outbreak of Coronavirus disease (COVID-19), first in Eastern Asia and then
essentially across the world has been declared a pandemic by the WHO. COVID-19 is …

There is an urgent need for antivirals to treat the newly emerged severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …