Aminoacyl-tRNA synthetases
MAR Gomez, M Ibba - Rna, 2020 - rnajournal.cshlp.org
The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
Homocysteine modification in protein structure/function and human disease
H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the
mechanism that balances OXPHOS activity and intracellular oxygen availability remains …
mechanism that balances OXPHOS activity and intracellular oxygen availability remains …
Aminoacyl-tRNA synthetases as therapeutic targets
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ
Q Zhou, WW Sun, JC Chen, HL Zhang, J Liu… - Nature …, 2022 - nature.com
Whether amino acids act on cellular insulin signaling remains unclear, given that increased
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …
Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes
The human genome contains 61 codons encoding 20 amino acids. Synonymous codons
representing a given amino acid are decoded by a set of transfer RNAs (tRNAs) called …
representing a given amino acid are decoded by a set of transfer RNAs (tRNAs) called …
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics
Tumourigenesis and cancer progression require enhanced global protein translation,–.
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy
WQ Zheng, JH Zhang, ZH Li, X Liu… - Proceedings of the …, 2023 - National Acad Sciences
Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …
Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs
MM Georgescu, MZ Islam, Y Li, J Traylor… - Acta Neuropathologica …, 2021 - Springer
Prognostic molecular subgrouping of glioblastoma is an ongoing effort and the current
classification includes IDH-wild-type and IDH-mutant entities, the latter showing significantly …
classification includes IDH-wild-type and IDH-mutant entities, the latter showing significantly …
Ribosome inactivation regulates translation elongation in neurons
B Popper, M Bürkle, G Ciccopiedi… - Journal of Biological …, 2024 - ASBMB
Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells
consistently reshape their translatome, and, consequently, their proteome. The control of …
consistently reshape their translatome, and, consequently, their proteome. The control of …