It has been over 50 years since the original serotonin hypothesis was proposed by the
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …

Aggression and violence represent a significant public health concern and a clinical
challenge for the mental healthcare provider. A great deal has been revealed regarding the …

Tryptophan is an indispensable amino acid that should to be supplied by dietary protein.
Apart from its incorporation into body proteins, tryptophan is the precursor for serotonin, an …

An essential component of the human diet, L-tryptophan is critical in a number of metabolic
functions and has been widely used in numerous research and clinical trials. This review …

5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of
emotional, cognitive and behavioural control processes. However, its precise contribution is …

Mood disorders collectively account for a substantial proportion of disease burden across
the globe and have a devastating impact on quality of life and occupational function. Here …

Chronic inflammation has been shown to contribute to the development of a wide variety of
disorders by means of a number of proposed mechanisms. Depression and cognitive …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Alterations in brain tryptophan levels cause changes in brain serotonin synthesis, and this
has been used to study the implication of altered serotonin levels in humans. In the acute …

Serotonergic dysfunction is thought to contribute to the pathophysiology of schizophrenia but
the evidence has not been systematically synthesised before. We therefore systematically …