Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Atrial fibrillation from the pathologist's perspective

D Corradi - Cardiovascular pathology, 2014 - Elsevier
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia encountered in clinical
practice, is associated with increased morbidity and mortality. Electrophysiologically, it is …

Prevention of recurrent lone atrial fibrillation by the angiotensin-II converting enzyme inhibitor ramipril in normotensive patients

F Belluzzi, L Sernesi, P Preti, F Salinaro… - Journal of the American …, 2009 - jacc.org
Objectives: The aim of the present study was to verify whether angiotensin-II converting
enzyme (ACE) inhibition is also effective in preventing relapses of lone atrial fibrillation …

Monogenic atrial fibrillation as pathophysiological paradigms

S Mahida, SA Lubitz, M Rienstra, DJ Milan… - Cardiovascular …, 2011 - academic.oup.com
Atrial fibrillation (AF) is the most common cardiac rhythm abnormality and represents a major
burden, both to patients and to health-care systems. In recent years, increasing evidence …

Genes and atrial fibrillation: a new look at an old problem

D Fatkin, R Otway, JI Vandenberg - Circulation, 2007 - Am Heart Assoc
tial (Figure 1) and may be less reliant on currents involved in the late phases of
repolarization. 10 A number of ion channels that have a modest effect or that are closed …

Genetics of atrial fibrillation: implications for future research directions and personalized medicine

SA Lubitz, C Ozcan, JW Magnani, S Kääb… - Circulation …, 2010 - Am Heart Assoc
Atrial fibrillation (AF) was first described in humans approximately 100 years ago, 1 and
familial forms of AF were reported more than 70 years ago. 2, 3 Within the last 10 years, 3 …

Lone atrial fibrillation: what do we know?

D Kozlowski, S Budrejko, GYH Lip, J Rysz… - Heart, 2010 - heart.bmj.com
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice.
Despite the common association of AF with cardiovascular disease, some patients can be …

Genetics of atrial fibrillation

SA Lubitz, BA Yi, PT Ellinor - Cardiology clinics, 2009 - Elsevier
Recent studies of AF have identified mutations in a series of ion channels; however, these
mutations appear to be relatively rare causes of AF. A genome-wide association study has …

Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis

T Liu, P Korantzopoulos, G Xu, M Shehata, D Li… - Europace, 2011 - academic.oup.com
Aims Recent observations have raised concerns regarding the activation of the renin–
angiotensin system and the development of atrial fibrillation (AF). Some initial studies …

A genetic contribution to risk for postoperative junctional ectopic tachycardia in children undergoing surgery for congenital heart disease

KY Borgman, AH Smith, JP Owen, FA Fish… - Heart rhythm, 2011 - Elsevier
BACKGROUND: Junctional ectopic tachycardia (JET) is a common arrhythmia complicating
pediatric cardiac surgery, with many identifiable clinical risk factors but no genetic risk …