Targeting galectin-3 in inflammatory and fibrotic diseases

S Bouffette, I Botez, F De Ceuninck - Trends in Pharmacological Sciences, 2023 - cell.com
Abstract Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in
cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections …

Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice

JH Kim, N Michiko, IS Choi, Y Kim, JY Jeong… - Plos …, 2024 - journals.plos.org
Reactive astrocytes are associated with neuroinflammation and cognitive decline in diverse
neuropathologies; however, the underlying mechanisms are unclear. We used optogenetic …

Redox imbalance in neurological disorders in adults and children

F Rey, C Berardo, E Maghraby, A Mauri, L Messa… - Antioxidants, 2023 - mdpi.com
Oxygen is a central molecule for numerous metabolic and cytophysiological processes, and,
indeed, its imbalance can lead to numerous pathological consequences. In the human body …

Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation-induced cognitive impairment …

K Liu, Y Gao, X Wu, X Hu, C Shi, Q He, H Wu, H Yao… - …, 2025 - Elsevier
Neuroinflammation, characterized by activation of glial cells, plays a critical role in central
nervous system disorders. However, the precise mechanisms of neuroinflammation …

The compound (E)-2-(3, 4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's …

X Liu, W Wu, X Li, C Wang, K Chai, F Yuan… - Neural Regeneration …, 2025 - journals.lww.com
Alzheimer's disease (AD) is a neurological disease that causes cognitive impairment,
abnormal behavior, and personality changes, and eventually leads to dementia and death …

[HTML][HTML] Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression

G Pizzirusso, E Preka, J Goikolea… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease is a progressive neurological disorder causing memory loss and
cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration …

[HTML][HTML] Limbic system synaptic dysfunctions associated with prion disease onset

ST Foliaki, BR Groveman, EA Dews… - Acta …, 2024 - pmc.ncbi.nlm.nih.gov
Misfolding of normal prion protein (PrPC) to pathological isoforms (prions) causes prion
diseases (PrDs) with clinical manifestations including cognitive decline and mood-related …

Compound (E)-2-(3, 4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5× FAD …

X Liu, P Chen, W Wu, M Zhong, S Dong, H Lin, C Dai… - Life Sciences, 2024 - Elsevier
Aims Alzheimer's disease (AD) is characterized by β-amyloid (Aβ) aggregation and
neuroinflammation, leading to progressive synaptic loss and cognitive decline. Recent …

[HTML][HTML] Emerging role of galectin 3 in neuroinflammation and neurodegeneration

BM Lozinski, K Ta, Y Dong - Neural Regeneration Research, 2024 - journals.lww.com
Neuroinflammation and neurodegeneration are key processes that mediate the
development and progression of neurological diseases. However, the mechanisms …

半乳糖凝集素3 在神经炎症和神经退变中的新作用

BM Lozinski, K Ta, Y Dong - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
Neuroinflammation and neurodegeneration are key processes that mediate the
development and progression of neurological diseases. However, the mechanisms …