The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

The success of targeted therapies and immunotherapies has created optimism that cancers
may be curable. However, not all patients respond, drug resistance is common and many …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of
haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …