Pulmonary arterial hypertension: pathogenesis and clinical management
Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …
Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. An Official American Thoracic Society Research Statement
Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …
syndromes is a significant determinant of short-and long-term outcomes. Although …
The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure
The right ventricle (RV) is the major determinant of functional state and prognosis in
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
Cardiac fibrosis in the pressure overloaded left and right ventricle as a therapeutic target
K Schimmel, K Ichimura, S Reddy, F Haddad… - Frontiers in …, 2022 - frontiersin.org
Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …
Identification of microRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (polypyrimidine tract binding …
P Caruso, BJ Dunmore, K Schlosser, S Schoors… - Circulation, 2017 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …
[HTML][HTML] Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce …
Mitochondrial fission, regulated by dynamin-related protein-1 (Drp1), is a newly recognized
determinant of mitochondrial function, but its contribution to left ventricular (LV) impairment …
determinant of mitochondrial function, but its contribution to left ventricular (LV) impairment …
Fatty acid metabolic defects and right ventricular lipotoxicity in human pulmonary arterial hypertension
Background—The mechanisms of right ventricular (RV) failure in pulmonary arterial
hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have …
hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have …
BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension
I Cuthbertson, NW Morrell, P Caruso - Circulation research, 2023 - Am Heart Assoc
Pulmonary arterial hypertension forms the first and most severe of the 5 categories of
pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of …
pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of …