Congenital anomalies of the kidneys and urinary tracts (CAKUT) are disorders caused by
defects in the development of the kidneys and their outflow tracts. The formation of the …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer
and aging. Here, we show that senescence occurs during mammalian embryonic …

Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat
absorption. Defects in lymphatic vessel formation or function cause lymphedema. Here we …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

The vertebrate urogenital system forms due to inductive interactions between the Wolffian
duct, its derivative the ureteric bud, and their adjacent mesenchymes. These establish …

Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether
postnatal renal development follows a similar trajectory to normal in utero growth is …

Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival
factor for midbrain dopaminergic neurons. GDNF and related ligands, neurturin (NRTN) …

The goal of this study was the production of a decellularized kidney scaffold with structural,
mechanical, and physiological properties necessary for engineering basic renal structures in …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …