The inter-relationship between delirium and dementia: the importance of delirium prevention

TG Fong, SK Inouye - Nature Reviews Neurology, 2022 - nature.com
Delirium and dementia are two frequent causes of cognitive impairment among older adults
and have a distinct, complex and interconnected relationship. Delirium is an acute …

Can we improve delirium prevention and treatment in the emergency department? A systematic review

S Lee, H Chen, S Hibino, D Miller… - Journal of the …, 2022 - Wiley Online Library
Background This systematic review was conducted to evaluate any interventions to prevent
incident delirium, or shorten the duration of prevalent delirium, in older adults presenting to …

Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients

LO Watne, CT Pollmann, BE Neerland… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND The kynurenine pathway (KP) has been identified as a potential mediator
linking acute illness to cognitive dysfunction by generating neuroactive metabolites in …

Why is delirium more frequent in the elderly?

O Bugiani - Neurological Sciences, 2021 - Springer
An aging-related reduction in the brain's functional reserve may explain why delirium is
more frequent in the elderly than in younger people insofar as the reserve becomes …

International drive to illuminate delirium: a developing public health blueprint for action

AS Khachaturian, KM Hayden, JW Devlin… - Alzheimer's & …, 2020 - Wiley Online Library
† The views expressed in this paper are those of the author and not necessarily of the
authors' organizations including the US Administration for Community Living/Administration …

Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network

SM Vasunilashorn, N Lunardi… - Alzheimer's & …, 2023 - Wiley Online Library
Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimer's
disease (AD) and AD‐related dementias (ADRD) as a risk factor and outcome. Human …

Effects of ramelteon on the prevention of postoperative delirium in older patients undergoing orthopedic surgery: the RECOVER randomized controlled trial

ES Oh, JM Leoutsakos, PB Rosenberg… - The American Journal of …, 2021 - Elsevier
Objectives Postoperative delirium, associated with negative consequences including longer
hospital stays and worse cognitive and physical outcomes, is frequently accompanied by …

Proteomics for the discovery of clinical delirium biomarkers: a systematic review of major studies

K Wiredu, E Aduse-Poku, S Shaefi… - Anesthesia & …, 2023 - journals.lww.com
Delirium represents a significant health care burden, diagnosed in more than 2 million
elderly Americans each year. In the surgical population, delirium remains the most common …

Delirium detection in the emergency department: A diagnostic accuracy meta‐analysis of history, physical examination, laboratory tests, and screening instruments

CR Carpenter, S Lee, M Kennedy… - Academic …, 2024 - Wiley Online Library
Introduction Geriatric emergency department (ED) guidelines emphasize timely identification
of delirium. This article updates previous diagnostic accuracy systematic reviews of history …

Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature

AH Phing, S Makpol, ML Nasaruddin… - International Journal of …, 2023 - mdpi.com
Delirium, a common form of acute brain dysfunction, is associated with increased morbidity
and mortality, especially in older patients. The underlying pathophysiology of delirium is not …