Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases

Z Shen, W Huang, J Liu, J Tian, S Wang… - Frontiers in …, 2021 - frontiersin.org
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …

Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

Immunobiology of mesenchymal stem cells

S Ma, N Xie, W Li, B Yuan, Y Shi, Y Wang - Cell Death & Differentiation, 2014 - nature.com
Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …

Interactions between mesenchymal stem cells and the immune system

N Li, J Hua - Cellular and Molecular Life Sciences, 2017 - Springer
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess
immunomodulatory functions that have been investigated as potential treatments in various …

Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives

X Liang, Y Ding, Y Zhang, HF Tse… - Cell …, 2014 - journals.sagepub.com
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …

Mesenchymal stem cells secrete immunologically active exosomes

B Zhang, Y Yin, RC Lai, SS Tan… - Stem cells and …, 2014 - liebertpub.com
Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …

Effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis

L Bai, H Shao, H Wang, Z Zhang, C Su, L Dong, B Yu… - Scientific reports, 2017 - nature.com
We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental
autoimmune uveoretinitis (EAU) in rats. Recently, MSC-derived exosomes (MSC-Exo) were …

Mechanisms of mesenchymal stromal cell immunomodulation

K English - Immunology and cell biology, 2013 - Wiley Online Library
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the
fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years …

Comparing the immunomodulatory properties of bone marrow, adipose tissue, and birth-associated tissue mesenchymal stromal cells

P Mattar, K Bieback - Frontiers in immunology, 2015 - frontiersin.org
Mesenchymal stromal cells (MSC) have gained immense attraction in regenerative
medicine, tissue engineering, and immunotherapy. This is based on their differentiation …

[HTML][HTML] Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

B Zhang, RWY Yeo, RC Lai, EWK Sim, KC Chin… - Cytotherapy, 2018 - Elsevier
Background aims The immunomodulatory property of mesenchymal stromal cell (MSC)
exosomes is well documented. On the basis of our previous report that MSC exosomes …