Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming
incidence rate and a huge burden on health care providers. DM is characterized by the …

Background Natural food products have been used for combating human diseases for
thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones …

Diabetes mellitus is a metabolic disorder with chronic high blood glucose levels, and it is
associated with defects in insulin secretion, insulin resistance, or both. It is also a major …

Diabetes is both an endocrine and a metabolic disease affecting large numbers of
individuals worldwide. The use of natural products such as herbs in the management of …

Polyphenols are natural bioactives occurring in medicinal and aromatic plants and food and
beverages of plant origin. Compared with conventional therapies, plant-derived …

The clinical relationship between diabetes and inflammation is well established. Evidence
clearly indicates that disrupting oxidant-antioxidant equilibrium and elevated lipid …

Fisetin (3, 7, 3′, 4′-tetrahydroxyflavone) is a bioflavonoid found in fruits and vegetables. It
exhibits a wide variety of pharmacological properties, including antioxidant, antiinflammatory …

Liver plays a vital role in blood glucose homeostasis. Recent studies have provided
considerable evidence that hepatic glucose production (HGP) plays an important role in the …

Flavonoids are tricyclic polyphenolic compounds naturally occurring in plants. Being
nature's antioxidants flavonoids have been shown to reduce the damages induced by …

The bioactive flavonoid fisetin (FS) is a diet-derived antioxidant that is being increasingly
investigated for its health-promoting effects. Unfortunately, the poor physicochemical and …