Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been
replaced by models that postulate a disruption in parallel distributed or dynamic circuits …

Increasing evidence from neuroimaging and behavioral studies suggests that functional
disturbances within cortico-striato-thalamic pathways are critical to psychotic symptom …

• Using positron emission tomography, we studied cerebral glucose metabolism in drug-free,
age-and sex-matched, righthanded patients with unipolar depression (n= 10), bipolar …

The effects of the indolehallucinogen psilocybin, a mixed 5-HT 2 and 5-HT 1 agonist, on
regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET …

Positron emission tomography was used to study the relationship between rCBF and
symptom profiles in 30 schizophrenic patients. Factor analysis confirmed that the symptoms …

Background: Schizophrenic patients show various deficits in cognitive functions that have
been difficult to understand in terms of a common unifying hypothesis. Previously described …

• The" hypofrontality hypothesis" has been supported by many neuroimaging studies, but not
all, perhaps because of heterogeneity of samples. The present study examined three …

Neurological complications from cocaine use are well recognized. We propose that chronic
cocaine use can also cause clinically silent brain dysfunction. We investigated brain glucose …

The authors investigated changes in brain function associated with cocaine dependence
and withdrawal to provide clues regarding the processes that lead to the uncontrollable self …

Considerable evidence from preclinical and clinical investigations implicates disturbances of
brain dopamine (DA) function in the pathophysiology of several psychiatric and neurologic …