Prognostic and predictive molecular biomarkers for colorectal cancer: updates and challenges
E Koncina, S Haan, S Rauh, E Letellier - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …
heterogeneous disease is characterized by alterations in multiple molecular pathways …
Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide.
Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical …
Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical …
Validation of microsatellite instability detection using a comprehensive plasma-based genotyping panel
J Willis, MI Lefterova, A Artyomenko, PM Kasi… - Clinical Cancer …, 2019 - AACR
Purpose: To analytically and clinically validate microsatellite instability (MSI) detection using
cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using …
cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using …
CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models
Colorectal cancers (CRCs) can be divided into four gene expression-based biologically
distinct consensus molecular subtypes (CMS). This classification provides a potential …
distinct consensus molecular subtypes (CMS). This classification provides a potential …
Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
Q Zhu, X Zhao, Y Zhang, Y Li, S Liu, J Han… - Nature …, 2023 - nature.com
Human cancer cell lines have long served as tools for cancer research and drug discovery,
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …
Colorectal cancer consensus molecular subtypes translated to preclinical models uncover potentially targetable cancer cell dependencies
Purpose: Response to standard oncologic treatment is limited in colorectal cancer. The gene
expression–based consensus molecular subtypes (CMS) provide a new paradigm for …
expression–based consensus molecular subtypes (CMS) provide a new paradigm for …
Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines
Background Relapse and metastasis in colorectal cancer (CRC) are often attributed to
cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug …
cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug …
Exploring and modelling colon cancer inter-tumour heterogeneity: opportunities and challenges
Colon cancer inter-tumour heterogeneity is installed on multiple levels, ranging from (epi)
genetic driver events to signalling pathway rewiring reflected by differential gene expression …
genetic driver events to signalling pathway rewiring reflected by differential gene expression …
Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways
M Wan, Y Wang, Z Zeng, B Deng, B Zhu… - Bioscience …, 2020 - portlandpress.com
Colorectal cancer (CRC) is the third most common malignancy and one of the leading
causes of cancer-related death among men worldwide. CRC is a multifactor digestive …
causes of cancer-related death among men worldwide. CRC is a multifactor digestive …
Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status
CD Fleming-de-Moraes, MR Rocha… - Cancer biology & …, 2022 - Taylor & Francis
ABSTRACT The PI3K/Akt and Wnt/β-catenin pathways play an important role in the
acquisition of the malignant phenotype in cancer. However, there are few data regarding the …
acquisition of the malignant phenotype in cancer. However, there are few data regarding the …