ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 1 of 2—evidence base …

S Dorbala, Y Ando, S Bokhari… - Circulation …, 2021 - Am Heart Assoc
Sharmila Dorbala, MD, MPH, FASNC, Chair*; Yukio Ando, MD, PhD†; Sabahat Bokhari,
MD‡; Angela Dispenzieri, MD § ; Rodney H. Falk, MD*; Victor A. Ferrari, MD∥; Marianna …

AL (light-chain) cardiac amyloidosis: a review of diagnosis and therapy

RH Falk, KM Alexander, R Liao, S Dorbala - Journal of the American …, 2016 - jacc.org
The amyloidoses are a group of protein-folding disorders in which≥ 1 organ is infiltrated by
proteinaceous deposits known as amyloid. The deposits are derived from 1 of several …

How to image cardiac amyloidosis: a practical approach

S Dorbala, S Cuddy, RH Falk - Cardiovascular Imaging, 2020 - jacc.org
Cardiac amyloidosis (CA) is one of the most rapidly progressive forms of heart disease, with
a median survival from diagnosis, if untreated, ranging from< 6 months for light chain …

Cardiac amyloidosis: an update on pathophysiology, diagnosis, and treatment

OK Siddiqi, FL Ruberg - Trends in cardiovascular medicine, 2018 - Elsevier
The amyloidoses are a group of systemic diseases characterized by organ deposition of
misfolded protein fragments of diverse origins. The natural history of the disease …

Mitochondria and endothelial function

MA Kluge, JL Fetterman, JA Vita - Circulation research, 2013 - Am Heart Assoc
In contrast to their role in cell types with higher energy demands, mitochondria in endothelial
cells primarily function in signaling cellular responses to environmental cues. This article …

Exenatide protects against glucose-and lipid-induced endothelial dysfunction: evidence for direct vasodilation effect of GLP-1 receptor agonists in humans

J Koska, M Sands, C Burciu, KM D'Souza… - Diabetes, 2015 - Am Diabetes Assoc
GLP-1 receptor (GLP-1R) agonists may improve endothelial function (EF) via metabolic
improvement and direct vascular action. The current study determined the effect of GLP-1R …

Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish

S Mishra, J Guan, E Plovie, DC Seldin… - American Journal …, 2013 - journals.physiology.org
Systemic amyloid light-chain (AL) amyloidosis is associated with rapidly progressive and
fatal cardiomyopathy resulting from the direct cardiotoxic effects of circulating AL light chain …

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain‐mediated cardiotoxicity

J Guan, S Mishra, Y Qiu, J Shi, K Trudeau… - EMBO molecular …, 2014 - embopress.org
AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin
light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid …

Diagnostic utility of cardiac troponin T level in patients with cardiac amyloidosis

S Takashio, M Yamamuro, Y Izumiya… - ESC heart …, 2018 - Wiley Online Library
Aim The aim of this study was to evaluate the diagnostic utility of high‐sensitivity cardiac
troponin T (hs‐cTnT) levels in discriminating cardiac amyloidosis from patients with cardiac …

Effectiveness and safety of oral anticoagulants in cardiac amyloidosis: lights and shadows

D Di Lisi, L Di Caccamo, G Damerino… - Current Problems in …, 2023 - Elsevier
Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy characterized by extracellular
deposition of mis-folded proteins called amyloid. Cardiac complications of CA are several …