α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino
acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA …

Great successes have been achieved in developing small-molecule kinase inhibitors as
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …

Polo-like kinase 1 (Plk1) plays key roles in regulating mitotic processes that are crucial for
cellular proliferation. Overexpression of Plk1 is tightly associated with the development of …

Parkinson's Disease (PD) is characterized both by the loss of dopaminergic neurons in the
substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These …

Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is
considered as a prominent factor to initiate and aggravate the neurodegeneration in …

Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares
the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other …

Phosphorylation of alpha-synuclein at serine-129 is an important marker of pathologically
relevant, aggregated forms of the protein in several important human diseases, including …

Morpholines and morpholinones are important building blocks in organic synthesis and
pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines …

Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many
living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or …

Abstract α-Synuclein plays a central role in synucleinopathies pathogenesis such as
Parkinson's disease (PD). Phosphorylation is the most common and important protein …