Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury

BS Bregman, JV Coumans, HN Dai, PL Kuhn… - Progress in brain …, 2002 - Elsevier
Publisher Summary Experimental conditions altering the intrinsic capacity of mature central
nervous system (CNS) neurons for growth and those that modify the environment at the …

Cellular transplantation strategies for spinal cord injury and translational neurobiology

PJ Reier - NeuroRx, 2004 - Elsevier
Basic science advances in spinal cord injury and regeneration research have led to a variety
of novel experimental therapeutics designed to promote functionally effective axonal …

Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection

DM Basso, MS Beattie, JC Bresnahan - Experimental neurology, 1996 - Elsevier
Injury reproducibility is an important characteristic of experimental models of spinal cord
injuries (SCI) because it limits the variability in locomotor and anatomical outcome …

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

JW McDonald, XZ Liu, Y Qu, S Liu, SK Mickey… - Nature medicine, 1999 - nature.com
Transplantation approaches using cellular bridges 1, 2, fetal central nervous system cells 3,
4, 5, fibroblasts expressing neurotrophin-3 (ref. 6), hybridoma cells expressing inhibitory …

Rho signaling pathway targeted to promote spinal cord repair

P Dergham, B Ellezam, C Essagian… - Journal of …, 2002 - Soc Neuroscience
The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins

JV Coumans, TTS Lin, HN Dai, L MacArthur… - Journal of …, 2001 - Soc Neuroscience
Little axonal regeneration occurs after spinal cord injury in adult mammals. Regrowth of
mature CNS axons can be induced, however, by altering the intrinsic capacity of the neurons …

Lineage-restricted neural precursors survive, migrate, and differentiate following transplantation into the injured adult spinal cord

AC Lepore, I Fischer - Experimental neurology, 2005 - Elsevier
Fetal spinal cord from embryonic day 14 (E14/FSC) has been used for numerous
transplantation studies of injured spinal cord. E14/FSC consists primarily of neuronal (NRP) …

Behavioral testing after spinal cord injury: congruities, complexities, and controversies

DM Basso - Journal of neurotrauma, 2004 - liebertpub.com
Selection and implementation of behavioral tests in spinal cord injury research is an
important process, and yet few papers have focused on these issues. The critical component …

Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats

NJ Tester, DR Howland - Experimental neurology, 2008 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) are upregulated in the central nervous system
following injury. Chondroitin sulfate glycosaminoglycan (CS GAG) side chains substituted on …

Feasibility and safety of neural tissue transplantation in patients with syringomyelia

ED Wirth Iii, PJ Reier, RG Fessler… - Journal of …, 2001 - liebertpub.com
Transplantation of fetal spinal cord (FSC) tissue has demonstrated significant potential in
animal models for achieving partial anatomical and functional restoration following spinal …