Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions

A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

R Limbocker, S Errico, D Barbut, TPJ Knowles… - Natural Product …, 2022 - pubs.rsc.org
Covering: 1993 to 2021 (mainly 2017–2021) Alzheimer's and Parkinson's diseases are
neurodegenerative conditions affecting over 50 million people worldwide. Since these …

Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers

R Limbocker, R Staats, S Chia, FS Ruggeri… - Frontiers in …, 2021 - frontiersin.org
The aberrant aggregation of proteins is a key molecular event in the development and
progression of a wide range of neurodegenerative disorders. We have shown previously …

From marine metabolites to the drugs of the future: Squalamine, trodusquemine, their steroid and triterpene analogues

O Kazakova, G Giniyatullina, D Babkov… - International journal of …, 2022 - mdpi.com
This review comprehensively describes the recent advances in the synthesis and
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …

Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease

F Muhammad, Y Liu, N Wang, L Zhao… - ACS Chemical …, 2022 - ACS Publications
Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the
central nervous system in the elderly, causing motor impediments and cognitive …

A brain-permeable aminosterol regulates cell membranes to mitigate the toxicity of diverse pore-forming agents

RP Kreiser, AK Wright, LR Sasser… - ACS chemical …, 2022 - ACS Publications
The molecular composition of the plasma membrane plays a key role in mediating the
susceptibility of cells to perturbations induced by toxic molecules. The pharmacological …

Can allostery be a key strategy for targeting PTP1B in drug discovery? A lesson from trodusquemine

R Maccari, R Ottanà - International Journal of Molecular Sciences, 2023 - mdpi.com
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme crucially implicated in aberrations of
various signaling pathways that underlie the development of different human pathologies …

Exploring Caenorhabditis elegans as Parkinson's Disease Model: Neurotoxins and Genetic Implications

LPD da Silva, E da Cruz Guedes, ICO Fernandes… - Neurotoxicity …, 2024 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world, the first being Alzheimer's disease. Patients with PD have a loss of dopaminergic …

2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic …

S Promtang, T Sanguanphun, P Chalorak… - ACS Chemical …, 2024 - ACS Publications
Aggregative α-synuclein and incurring oxidative stress are pivotal cascading events, leading
to dopaminergic (DAergic) neuronal loss and contributing to clinical manifestations of …

Ergothioneine exerts neuroprotective effects in Parkinson's disease: Targeting α-synuclein aggregation and oxidative stress

W Gao, Y Wang, F Wang, X Wu, F Lu, F Liu - Food Research International, 2024 - Elsevier
Ergothioneine (EGT) is a natural dietary antioxidant derived from certain edible mushrooms,
commonly used as a food additive and supplement, but its effects on Parkinson's Disease …