The vascular supply to the human bladder is derived mainly from the superior and inferior
vesical arteries, the latter being directly connected to the internal iliac artery. Aging is …

Objective: Despite the various treatment and prevention options for catheter-related bladder
discomfort (CRBD), many uncertainties persist in clinical practice. To systematically review …

Background Inflammation is often associated with several bladder dysfunctions, including
overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such …

Aim To review evidence for novel drug targets that can manage overactive bladder (OAB)
symptoms. Methods A think tank considered evidence from the literature and their own …

Contractile behaviour of the urinary bladder and its sympathetic inhibition during storage
phases are not well understood. Here, we explore muscularis mucosae (MM) as a …

Key points In the bladder suburothelial microvasculature, pericytes in different microvascular
segments develop spontaneous Ca2+ transients with or without associated constrictions …

The bladder mucosa is comprised of the multilayered urothelium, lamina propria (LP),
microvasculature, and smooth muscle fibers (muscularis mucosae). The muscularis …

The microvasculature is composed of arterioles, capillaries and venules. Spontaneous
arteriolar constrictions reduce effective vascular resistance to enhance tissue perfusion …

Aims Historically, urine has been viewed primarily as a waste product with little biological
role in the overall health of an individual. Increasingly, data suggest that urine plays a role in …

Abstract Properties of spontaneous Ca 2+ transients in the myenteric microvasculature of the
guinea-pig stomach were investigated. Specifically, we explored the spatio-temporal origin …