Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

Information in mRNA has largely been thought to be confined to its nucleotide sequence.
However, the advent of mapping techniques to detect modified nucleotides has revealed …

Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Chemical modifications on mRNA represent a critical layer of gene expression regulation.
Research in this area has continued to accelerate over the last decade, as more …

While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …