Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …

Coupling of two distinct pharmacophores, tacrine and trolox, endowed with different
biological properties, afforded 21 hybrid compounds as novel multifunctional candidates …

A combination of tacrine and tryptophan led to the development of a new family of
heterodimers as multi-target agents with potential to treat Alzheimer's disease. Based on the …

Dementia is a term used to define different brain disorders that affect memory, thinking,
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug,
have been developed and evaluated as potential anti Alzheimer's disease (AD) agents. The …

Cardanol is a phenolic lipid component of cashew nut shell liquid (CNSL), obtained as the
byproduct of cashew nut food processing. Being a waste product, it has attracted much …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

Due to the putative role of butyrylcholinesterase (BChE) in regulation of acetylcholine levels
and functions in the late stages of the Alzheimer's disease (AD), the potential of selective …