Vitiligo: a review

C Bergqvist, K Ezzedine - Dermatology, 2020 - karger.com
Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of
the population worldwide. The disease is characterized by the selective loss of melanocytes …

[HTML][HTML] Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

JL Collier, SA Weiss, KE Pauken, DR Sen… - Nature …, 2021 - nature.com
CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …

Anatomically distinct fibroblast subsets determine skin autoimmune patterns

Z Xu, D Chen, Y Hu, K Jiang, H Huang, Y Du, W Wu… - Nature, 2022 - nature.com
The skin serves as a physical barrier and an immunological interface that protects the body
from the external environment,–. Aberrant activation of immune cells can induce common …

Mechanisms of melanocyte death in vitiligo

J Chen, S Li, C Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Vitiligo: a focus on pathogenesis and its therapeutic implications

C Bergqvist, K Ezzedine - The Journal of dermatology, 2021 - Wiley Online Library
Vitiligo is the most common depigmenting disorder affecting 0.1%–2% of the population
worldwide. The characteristic white patches result from the selective loss of melanocytes …

Vitiligo: mechanisms of pathogenesis and treatment

ML Frisoli, K Essien, JE Harris - Annual review of immunology, 2020 - annualreviews.org
Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes
and results in patches of depigmentation that are visible as white spots. Recent research …

[HTML][HTML] Targeting the Janus kinase family in autoimmune skin diseases

MD Howell, FI Kuo, PA Smith - Frontiers in immunology, 2019 - frontiersin.org
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …

scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in Treg function

KJ Gellatly, JP Strassner, K Essien, MA Refat… - Science translational …, 2021 - science.org
Vitiligo is an autoimmune skin disease characterized by the targeted destruction of
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …

Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy

K Boniface, J Seneschal, M Picardo, A Taïeb - Clinical reviews in allergy & …, 2018 - Springer
Vitiligo is an acquired chronic depigmenting disorder of the skin, with an estimated
prevalence of 0.5% of the general population, characterized by the development of white …

Vitiligo: a comprehensive overview: part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work …

A Alikhan, LM Felsten, M Daly… - Journal of the American …, 2011 - Elsevier
Vitiligo is an acquired pigmentary disorder of unknown etiology that is clinically
characterized by the development of white macules related to the selective loss of …