Peptide‐based diagnostic and therapeutic agents: Where we are and where we are heading?

MP Khalily, M Soydan - Chemical Biology & Drug Design, 2023 - Wiley Online Library
Peptides are increasingly present in all branches of medicine as innovative drugs, imaging
agents, theragnostic, and constituent moieties of other sophisticated drugs such as peptide …

Polymeric nanoparticles as a promising platform for treating triple-negative breast cancer: Current status and future perspectives

MA Bazzazan, P Fathollazadeh, SK Shahbaz… - International Journal of …, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that
lacks expression of estrogen, progesterone, and HER2 receptor targets for therapy …

A Magnetic Resonance Imaging‐Chemical Exchange Saturation Transfer (MRI‐CEST) Method for the Detection of Water Cycling across Cellular Membranes

E Di Gregorio, C Papi, L Conti, A Di Lorenzo… - Angewandte …, 2024 - Wiley Online Library
Water cycling across the membrane transporters is considered a hallmark of cellular
metabolism and it could be of high diagnostic relevance in the characterization of tumors …

Delivery of RGD-modified liposome as a targeted colorectal carcinoma therapy and its autophagy mechanism

Y Ren, B Yuan, S Hou, Y Sui, T Yang, M Lv… - Journal of Drug …, 2021 - Taylor & Francis
Liposomes are among the most extensively applied drug carriers due to their excellent
biocompatibility, controllable size and ease of modification. In the present study, we …

[HTML][HTML] Evaluation of physicochemical properties, pharmacokinetics, biodistribution, toxicity, and contrast-enhanced cancer MRI of a cancer-targeting contrast agent …

Y Li, S Gao, H Jiang, N Ayat, V Laney… - Investigative …, 2022 - journals.lww.com
Objectives Preclinical assessments were performed according to the US Food and Drug
Administration guidelines to determine the physicochemical properties, pharmacokinetics …

RGD_PLGA nanoparticles with docetaxel: a route for improving drug efficiency and reducing toxicity in breast cancer treatment

E Di Gregorio, C Romiti, A Di Lorenzo, F Cavallo… - Cancers, 2022 - mdpi.com
Simple Summary Breast cancer is the most prevalent cancer in women and the leading
cause of cancer-associated deaths. Although several therapeutic approaches are available …

Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting

Y Wang, Z Ding, S Lv, J Liu, J Pan, Y Yu… - Journal of Liposome …, 2023 - Taylor & Francis
Abstract tLyP-1 peptide is verified to recognize neuropilin (NRP) receptors overexpressed
on the surface of both glioma cells and endothelial cells of angiogenic blood vessels. In the …

Reliable assessment of swine renal fibrosis using quantitative magnetization transfer imaging

K Jiang, CM Ferguson, RC Grimm, X Zhu… - Investigative …, 2022 - journals.lww.com
Objectives Quantitative magnetization transfer (qMT) is useful for measurement of murine
renal fibrosis at high and ultrahigh field strengths. However, its utility at clinical field …