In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …

The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal
transduction of steroid hormone receptors. Both proteins have been implicated in prostate …

Given their clinical importance for the treatment of acute and chronic neurodegenerative
diseases in humans including nerve injuries (eg Alzheimer's disease, Parkinson's disease …

On the basis of the new finding that the protein synthesis inhibitor cycloheximide (1, 4-[2-(3,
5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2, 6-piperidinedione) is able to competitively …

The structure-based design and subsequent chemical synthesis of novel, urea-containing
FKBP12 inhibitors are described. These compounds are shown to disrupt the cis− trans …

O564924A2 5/1992 WO9535308 12/1985 WO920. 0278 1/1992 WO9204370 3/1992
WO921 6501 10/1992 WO9219593 11/1992 WO9219745 11/1992 WO922. 313 12/1992 …

This invention relates to neurotrophic compounds having an affinity for FKBP-type
immunophilins, their preparation and use as inhibitors of the enzyme activity associated with …

Lyons, W. Ernest et al..“Neuronal Regeneration Enhances the Expression of the
Irnrnunophilin FKBP-12,” The Jour nal of Neuroscience, 1995, 15, 2985-94. Hayward, CM, et …

This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid
isosteres, their preparation and use for treating neurological disorders including physically …

EP 405994 1/1991 EP 419049 3/1991 EP 468339 1/1992 EP 572365 12/1993 EP 652229
5/1995 GB 2247456 3/1992 JP 05178824 7/1993 WO WO9313066 7/1983 WO WO8809789 …