Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Yeast mitochondria: an overview of mitochondrial biology and the potential of mitochondrial systems biology

C Malina, C Larsson, J Nielsen - FEMS yeast research, 2018 - academic.oup.com
Mitochondria are dynamic organelles of endosymbiotic origin that are essential components
of eukaryal cells. They contain their own genetic machinery, have multicopy genomes and …

A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism

H Lu, F Li, BJ Sánchez, Z Zhu, G Li, I Domenzain… - Nature …, 2019 - nature.com
Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide
a platform for model simulations and integrative analysis of omics data. This study …

Genome-scale modeling of yeast metabolism: retrospectives and perspectives

Y Chen, F Li, J Nielsen - FEMS Yeast Research, 2022 - academic.oup.com
Yeasts have been widely used for production of bread, beer and wine, as well as for
production of bioethanol, but they have also been designed as cell factories to produce …

Automated engineering of synthetic metabolic pathways for efficient biomanufacturing

I Otero-Muras, P Carbonell - Metabolic Engineering, 2021 - Elsevier
Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …

[HTML][HTML] Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

ACA van Aalst, SC de Valk, WM van Gulik… - Synthetic and systems …, 2022 - Elsevier
Product yield on carbohydrate feedstocks is a key performance indicator for industrial
ethanol production with the yeast Saccharomyces cerevisiae. This paper reviews pathway …

Development and Perspective of Rhodotorula toruloides as an Efficient Cell Factory

Y Yu, S Shi - Journal of Agricultural and Food Chemistry, 2023 - ACS Publications
Rhodotorula toruloides is receiving significant attention as a novel cell factory because of its
high production of lipids and carotenoids, fast growth and high cell density, as well as the …

Multidimensional engineering of Saccharomyces cerevisiae for the efficient production of heme by exploring the cytotoxicity and tolerance of heme

Q Guo, J Li, MR Wang, M Zhao, G Zhang, S Tang… - Metabolic …, 2024 - Elsevier
Heme has attracted considerable attention due to its indispensable biological roles and
applications in healthcare and artificial foods. The development and utilization of edible …

Multiscale models quantifying yeast physiology: towards a whole-cell model

H Lu, EJ Kerkhoven, J Nielsen - Trends in Biotechnology, 2022 - cell.com
The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important
eukaryal model organism for studying cellular physiology related to human health and …

A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data

HV Dinh, PF Suthers, SHJ Chan, Y Shen, T Xiao… - Metabolic Engineering …, 2019 - Elsevier
Rhodosporidium toruloides is a red, basidiomycetes yeast that can accumulate a large
amount of lipids and produce carotenoids. To better assess this non-model yeast's metabolic …