The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Highlights•Activation induces a programmed timed division burst before return to
quiescence.•Clonal integration of activation signals, stochastic probabilities and ongoing …

A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting
host autoimmunity. We investigated homeostatic control of self-activated T cells within …

MHC class I–associated peptides (MAPs) define the immune self for CD8+ T lymphocytes
and are key targets of cancer immunosurveillance. Here, the goals of our work were to …

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …

CD28 and CTLA4 are T cell coreceptors that competitively engage B7 ligands CD80 and
CD86 to control adaptive immune responses. While the role of CTLA4 in restraining CD28 …

T-cell antigen receptor (TCR) signaling is essential for activation, proliferation, and effector
function of T cells. Modulation of both intensity and duration of TCR signaling can regulate …

Lymphocytes integrate Ag and cytokine receptor signals to make cell fate decisions. Using a
specific reporter of TCR signaling that is insensitive to cytokine signaling, Nur77-eGFP, we …

Highlights•Immune system plays a critical role in maintaining homeostasis of the human
body.•Development of immune-system-on-a-chip platforms is in its infancy.•Several …

One of the feats of adaptive immunity is its ability to recognize foreign pathogens while
sparing the self. During maturation in the thymus, T cells are selected through the binding …