DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks

KN Kreuzer - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
Recent advances in the area of bacterial DNA damage responses are reviewed here. The
SOS pathway is still the major paradigm of bacterial DNA damage response, and recent …

[HTML][HTML] An insight into the mechanisms of homeostasis in extremophiles

A Somayaji, CR Dhanjal, R Lingamsetty… - Microbiological …, 2022 - Elsevier
The homeostasis of extremophiles is one that is a diamond hidden in the rough. The way
extremophiles adapt to their extreme environments gives a clue into the true extent of what is …

Radiation response in Deinococcus deserti: IrrE is a metalloprotease that cleaves repressor protein DdrO

M Ludanyi, L Blanchard, R Dulermo… - Molecular …, 2014 - Wiley Online Library
D einococcus bacteria are famous for their extreme radiation tolerance. The IrrE protein was
shown to be essential for radiation tolerance and, in an unelucidated manner, for induction …

Engineering of transcriptional regulators enhances microbial stress tolerance

Z Lin, Y Zhang, J Wang - Biotechnology advances, 2013 - Elsevier
Both prokaryotes and eukaryotes have pyramid-shaped hierarchical regulatory networks
that control gene transcription, enabling the cell to respond to natural environmental …

Global regulator IrrE on stress tolerance: a review

L Wang, YS Tan, K Chen, S Ntakirutimana… - Critical Reviews in …, 2024 - Taylor & Francis
Stress tolerance is a vital attribute for all living beings to cope with environmental
adversities. IrrE (also named PprI) from Deinococcus radiodurans enhances resistance to …

Protease activity of PprI facilitates DNA damage response: Mn (2+)-dependence and substrate sequence-specificity of the proteolytic reaction

Y Wang, Q Xu, H Lu, L Lin, L Wang, H Xu, X Cui… - PloS one, 2015 - journals.plos.org
The extremophilic bacterium Deinococcus radiodurans exhibits an extraordinary resistance
to ionizing radiation. Previous studies established that a protein named PprI, which exists …

Recent progress in understanding the molecular mechanisms of radioresistance in Deinococcus bacteria

AC Munteanu, V Uivarosi, A Andries - Extremophiles, 2015 - Springer
The deleterious effects of ionizing radiation are a major concern of the modern world. In the
last decades, outstanding interest has been given to developing new therapeutic tools …

RNA Sequencing and Proteogenomics Reveal the Importance of Leaderless mRNAs in the Radiation-Tolerant Bacterium Deinococcus deserti

A De Groot, D Roche, B Fernandez… - Genome biology and …, 2014 - academic.oup.com
Deinococcus deserti is a desiccation-and radiation-tolerant desert bacterium. Differential
RNA sequencing (RNA-seq) was performed to explore the specificities of its transcriptome …

Dendrobium officinale Kimura et Migo and American ginseng mixture: a Chinese herbal formulation for gut microbiota modulation

LIU Cheng-Zhi, C Wei, W Mei-Xia, W Ying… - Chinese journal of …, 2020 - Elsevier
Abstract Dendrobium officinale Kimura et Migo (D. officinale) is a famous traditional Chinese
medicine (TCM). A mixture of D. officinale and American ginseng has been shown to …

The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA

H Lu, Z Chen, T Xie, S Zhong, S Suo, S Song… - Nature …, 2024 - nature.com
Bacteria have evolved various response systems to adapt to environmental stress. A
protease-based derepression mechanism in response to DNA damage was characterized in …