1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …

Isatin has been widely used in drug discovery. The ring is part of many naturally occurring
compounds and is used to design compounds with diverse biological activities. These isatin …

Spirocyclic pyrrolidines are structural motifs frequently found in a wide variety of natural
products, pharmaceuticals and biologically significant compounds. In the past few years …

Novel dispirooxindole-pyrrolidine derivatives have been synthesized through 1, 3-dipolar
cycloaddition of an azomethine ylide generated from isatin and sarcosine with the …

Nitrogen-containing heterocyclic compounds are some of the most significant compounds
that are produced artificially or naturally. These heterocyclic rings are virtually always …

Catalytic asymmetric construction of the biologically important spiro [pyrrolidin‐3, 2′‐
oxindole] scaffold with contiguous quaternary stereogenic centers in excellent …

The 1, 3-dipolar cycloaddition of azomethine ylides derived from substituted isatins and 1, 3-
thiazolane-4-carboxylic acid to a series of 2-(arylmethylene)-2, 3-dihydro-1H-inden-1-ones …

Spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrid compounds were obtained
in excellent yields from the regio-and stereoselective reaction between β-nitrostyrenes and …