RNA sequencing: the teenage years

R Stark, M Grzelak, J Hadfield - Nature Reviews Genetics, 2019 - nature.com
Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …

Considerations for reproducible omics in aging research

PP Singh, BA Benayoun - Nature aging, 2023 - nature.com
Technical advancements over the past two decades have enabled the measurement of the
panoply of molecules of cells and tissues including transcriptomes, epigenomes …

[HTML][HTML] In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues

B Wang, A Kovalchuk, D Li, R Rodriguez-Juarez… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
With the current COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), there is an urgent need for new therapies and prevention …

An endophyte from salt-adapted Pokkali rice confers salt-tolerance to a salt-sensitive rice variety and targets a unique pattern of genes in its new host

MH Sampangi-Ramaiah, Jagadheesh, P Dey… - Scientific reports, 2020 - nature.com
Endophytes, both of bacterial and fungal origin, are ubiquitously present in all plants. While
their origin and evolution are enigmatic, there is burgeoning literature on their role in …

miR-128-3p inhibits intramuscular adipocytes differentiation in chickens by downregulating FDPS

S Zhu, B Zhang, T Zhu, D Wang, C Liu, Y Liu, Y He… - BMC genomics, 2023 - Springer
Background Intramuscular fat (IMF) content is the major indicator for evaluating chicken
meat quality due to its positive correlation with tenderness, juiciness, and flavor. An …

Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

S Gaikwad, F Ghobakhlou, DJ Young, J Visweswaraiah… - Elife, 2021 - elifesciences.org
In eukaryotes, 43S preinitiation complex (PIC) formation is a rate-determining step of
translation. Ribosome recycling following translation termination produces free 40S subunits …

Conservation of Nematocida microsporidia gene expression and host response in Caenorhabditis nematodes

YC Wan, ER Troemel, AW Reinke - PLoS One, 2022 - journals.plos.org
Microsporidia are obligate intracellular parasites that are known to infect most types of
animals. Many species of microsporidia can infect multiple related hosts, but it is not known if …

High heterogeneity undermines generalization of differential expression results in RNA-Seq analysis

W Cui, H Xue, L Wei, J Jin, X Tian, Q Wang - Human genomics, 2021 - Springer
Abstract Background RNA sequencing (RNA-Seq) has been widely applied in oncology for
monitoring transcriptome changes. However, the emerging problem that high variation of …

Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

BB Teefy, A Adler, A Xu, K Hsu, PP Singh… - Genome …, 2023 - genome.cshlp.org
Although germline cells are considered to be functionally “immortal,” both the germline and
supporting somatic cells in the gonad within an organism experience aging. With increased …

Ethylene signaling modulates tomato pollen tube growth through modifications of cell wall remodeling and calcium gradient

R Althiab‐Almasaud, Y Chen, E Maza, A Djari… - The Plant …, 2021 - Wiley Online Library
Ethylene modulates plant developmental processes including flower development. Previous
studies have suggested ethylene participates in pollen tube (PT) elongation, and both …