Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within
sensory neurones. Following primary infection, the virus replicates productively within …

Primary infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the
peripheral and central nervous system, upper respiratory tract, and gastrointestinal tract …

Cytomegalovirus latency depends on an interaction with hematopoietic cells in bone marrow
and peripheral blood. The distribution of viral DNA was investigated by PCR-driven in situ …

During herpes simplex virus (HSV) latency, the viral genome is harbored in peripheral
neurons in the absence of infectious virus but with the potential to restart infection. Advances …

Like other alpha-herpesviruses, Herpes Simplex Virus Type 1 (HSV-1) possesses the ability
to establish latency in sensory ganglia as a non-integrated, nucleosome-associated …

An important question in virology is the mechanism (s) by which persistent viruses such as
the herpesviruses and human immunodeficiency virus (HIV) establish a latent infection in …

After replicating in surface epithelia, herpes simplex virus type-1 (HSV-1) enters the axonal
terminals of peripheral neurons. The viral genome translocates to the nucleus, where it …

The clinical manifestations of herpes simplex virus infection generally involve a mild and
localized primary infection followed by asymptomatic (latent) infection interrupted …

Herpes simplex virus type 1 establishes latent infections in sensory neurons. During latency
only one locus, the latency-associated transcript (LAT), is abundantly transcribed. Several …

Publisher Summary Herpesviruses have been identified that infect nearly all groups of
vertebrates. This chapter focuses on the latency of α-herpesviruses. Several mammalian …