This review summarizes knowledge concerning a ubiquitous plasma transmembraneprotein
family that mediates nucleobase or ascorbate secondary active transport (NAT). We show …

Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …

Transporters are ubiquitous proteins mediating the translocation of solutes across cell
membranes, a biological process involved in nutrition, signaling, neurotransmission, cell …

The uric acid/xanthine H+ symporter, UapA, is a high-affinity purine transporter from the
filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a …

Aspergillus fumigatus is a ubiquitous soil decomposer and an opportunistic pathogen that is
characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an …

Transport assays allow the direct kinetic analysis of a specific transporter by measuring
apparent K m and V max values, and permit the characterization of substrate specificity …

UapA, a uric acid–xanthine permease of Aspergillus nidulans, has been used as a prototype
to study structure–function relationships in the ubiquitous nucleobase–ascorbate transporter …

The nucleobase-ascorbate transporter or nucleobase-cation symporter-2 (NAT/NCS2) family
is one of the five known families of transporters that use nucleobases as their principal …

We cloned and characterized an Aspergillus nidulans gene, called fcyB, encoding the
closest homologue to the yeast Fcy2p/Fcy21p permeases. Deletion of fcyB (ΔfcyB) does not …

The NAT family was defined by the cloning and characterization of the UapA27, 28 and
UapC29 uric acid-xanthine permeases of the ascomycete Aspergillus nidulans, and the …